Figure 4.
Reconstitution of NRP2 rescues the miR-331-3p-mediated inhibition of TNBC cells. A, NRP2 expression of TNBC cells with the transfection of Myc-NRP2. B and C, Restoration of NRP2 significantly abrogated the suppressive role of miR-331-3p on the proliferation of TNBC cells. D, Overexpression of NRP2 promoted the colony formation of MDA-MB-231 and HCC1937 cells that carrying miR-331-3p mimics. NRP2 indicates neuropilin-2; TNBC, triple-negative breast cancer.