Comparison 2. Oestrogen tablets versus placebo or other regimens.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Improvement in symptoms (participant‐assessed at end point)	4		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Oestrogen tablets versus oestrogen cream	2	208	Odds Ratio (M‐H, Fixed, 95% CI)	1.06 [0.55, 2.01]
1.2 Oestrogen tablets versus placebo	2	1638	Odds Ratio (M‐H, Fixed, 95% CI)	12.47 [9.81, 15.84]
2 Endometrial thickness	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Oestrogen tablets versus oestrogen cream	2	151	Odds Ratio (M‐H, Fixed, 95% CI)	0.31 [0.06, 1.60]
3 Improvement in symptoms (clinician‐assessed at end point)	6		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Oestrogen tablets versus oestrogen cream	3	528	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.70, 1.52]
3.2 Oestrogen tablets versus placebo	3	2078	Odds Ratio (M‐H, Fixed, 95% CI)	12.85 [10.39, 15.89]
4 Improvement in symptoms (decrease in vaginal pH at end point)	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 Oestrogen tablets versus oestrogen cream	1	48	Mean Difference (IV, Fixed, 95% CI)	0.20 [‐0.12, 0.52]
4.2 Oestrogen tablets versus placebo	2	524	Mean Difference (IV, Fixed, 95% CI)	‐0.95 [‐1.10, ‐0.80]
5 Improvement in symptoms (increase in maturation indices at end point)	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 Oestrogen tablets versus oestrogen cream	1	48	Mean Difference (IV, Fixed, 95% CI)	‐4.69 [‐13.58, 4.20]
5.2 Oestrogen tablets versus placebo	1	436	Mean Difference (IV, Fixed, 95% CI)	18.63 [14.57, 22.69]
6 Adverse events (breast disorders)	1		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 Oestradiol tablets versus oestriol tablets	1	96	Odds Ratio (M‐H, Fixed, 95% CI)	3.06 [0.12, 77.09]
7 Adverse events (total adverse events)	1		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 Oestrogen tablets versus placebo	1	309	Odds Ratio (M‐H, Fixed, 95% CI)	1.28 [0.24, 6.69]
8 Adherence to treatment	2		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 Oestrogen tablets versus oestrogen cream	1	53	Odds Ratio (M‐H, Fixed, 95% CI)	1.90 [0.41, 8.94]
8.2 Oestradiol tablets versus oestriol tablets	1	96	Odds Ratio (M‐H, Fixed, 95% CI)	2.69 [1.15, 6.31]