Mac Bride 2014.

Methods	2‐arm parallel RCT
Participants	38 postmenopausal women with bothersome symptoms of vulvo vaginal atrophy Inclusion criteria: healthy postmenopausal women with bothersome symptoms of vulvo vaginal atrophy Exclusion criteria: not reported
Interventions	Group A: very low dose oestradiol vaginal cream (n = 19) applied to the vagina daily for 2 weeks followed by twice weekly for 10 weeks Group B: placebo (n = 19) applied as described for the active treatment group Duration: 12 weeks
Outcomes	Vaginal pH, maturation index, symptoms relating to atrophy
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information was reported on randomisation process
Allocation concealment (selection bias)	Unclear risk	No information was provided on allocation concealment
Blinding (performance bias)	Unclear risk	No information was given with respect to the blinding of participants and/or personnel
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information was provided on the blinding of outcome assessment
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information was given on withdrawals/losses to follow‐up per treatment groups
Selective reporting (reporting bias)	Unclear risk	Although all the outcomes specified in the methods section ware reported no data were, however, available on any of the outcomes
Other bias	Unclear risk	Insufficient information was reported to make a conclusive judgement