Study	Reason for exclusion
Akrivis 2003	Design not relevant: not a RCT
Bazin 2011	Duration of intervention was less than 12 weeks
Chakravorty 1998	Design not relevant: no control or placebo group
Chompootaweep 1998	Duration of intervention less than 12 weeks: study only 8 weeks in length
Cicinelli 2003	Intervention not relevant
Delgado 2016	Duration of treatment was less than 12 weeks
Dyer 1982	Intervention not relevant: dose response study
Gass 2013	Design not relevant: survey
Gupta 2008	Participants not relevant: included healthy postmenopausal women with no symptoms of vaginal atrophy
Heimer 1992	Duration of intervention less than 12 weeks
Henriksson 1996	Design not relevant: no comparison group
Holmgren 1989	Intervention not relevant: dose response study
Jaisamrarn 2013	Duration of intervention was less than 12 weeks
Jokar 2016	Duration of treatment was less than 12 weeks
Long 2006	Participants not relevant: hysterectomised postmenopausal women
Marx 2004	Intervention not relevant: oral oestrogen
Mattsson 1983	Design not relevant: not a true RCT
Mattsson 1989	Duration of intervention less than 12 weeks: study only 9 weeks in length
Mazur 2005	Duration of intervention less than 12 weeks: study only 4 weeks in length
Mettler 1991	Intervention not relevant: dose response
Nilsson 1992	Duration of intervention less than 12 weeks: study only 4 weeks in length
Plotti 1994	Design not relevant: not a true RCT
Raymundo 2004	Design not relevant: no randomisation
Tolino 1990	Outcomes not relevant
Vaccaro 2013	Duration of interventions was less than 12 weeks
Vartiainen 1993	Design not relevant: not a true RCT