Exposure to treatment, days |
|
|
|
|
Mean |
232 (36.2) |
226 (48.0) |
228 (36.1) |
|
Median |
238 |
238 |
238 |
|
Treatment dose, mg, mean (SD) |
2.56 (1.48) mg/week Equivalent to 0.37 mg/day |
0.33 (0.19) mg/day Equivalent to 2.31 mg/week |
2.20 (0.74) mg/week Equivalent to 0.31 mg/day |
|
Mean adherence, % |
95.5 |
90.6 |
93.9 |
|
b) Extension period
|
|
|
|
|
|
Somapacitan/ Somapacitan
|
Daily GH/ Daily GH
|
Placebo/ Somapacitan
|
Daily GH/ Somapacitan
|
|
(N = 114)
|
(N = 52)
|
(N = 55)
|
(N = 51)
|
Exposure to treatment, days |
|
|
|
|
Mean |
355 (52.4) |
349 (48.8) |
357 (40.4) |
343 (76.6) |
Median |
364 |
364 |
364 |
364 |
Treatment dose in extension, mg, mean (SD) |
2.35 (1.30) mg/week Equivalent to 0.34 mg/day |
0.28 (0.16) mg/day Equivalent to 1.96 mg/week |
2.61 (1.40) mg/week Equivalent to 0.37 mg/day |
2.66 (1.37) mg/week Equivalent to 0.38 mg/day |
Mean adherence during extension, % |
94.7 |
91.9 |
89.8 |
94.7 |