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. 2020 Jan 22;12(2):91. doi: 10.3390/pharmaceutics12020091

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Serial magnetic resonance imaging. The number in the lower left-hand corner of each image indicates the number of weeks after different treatments. No significant differences among pretreatment brain abscesses in groups A (A0), B (B0), and C (C0) were observed. The abscesses in groups A and B enlarged progressively with obvious mass effect. Bilateral ventricle involvement was noted in group A (A2 and A6). The abscess volume increased and grew inwardly (B2) then crossed the midline (B6). The abscess volume decreased progressively in group C after injection of vancomycin-embedded poly(lactide-co-glycolide acid) microparticles (C2 and C6), and no perifocal edema was observed. (x 0.8).