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. 2020 Feb 23;12(2):191. doi: 10.3390/pharmaceutics12020191

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A,B) The particle size and TEM images of (A) MTO-SLNs and (B) MTO/βE-SLNs. (C) The differential scanning calorimetry (DSC) analysis of MTO powder, βE, blank SLN powder, physical mixture of drugs (MTO/βE) and blank SLNs powder, MTO/βE-SLNs powder. (D) The in vitro release of MTO and βE from MTO/βE-SLNs at pH 7.4. Data represent means ± SD (n = 3). ANOVA performed for the release profile of MTO and βE after 24 h reveals a statistically reliable difference at 95% confidence. The accumulated release of MTO was observed to be higher than that of βE after 24 h. Both MTO and βE exhibited a similar release tendency of the drug in this study.