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. 2020 Feb 23;12(2):191. doi: 10.3390/pharmaceutics12020191

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The drug plasma concentration–time curve of MTO after an intravenous injection of free MTO and MTO/βE-SLNs at a dose of 2 mg/kg. (B) The drug plasma concentration–time curve of βE after an intravenous injection of free βE and MTO/βE-SLNs at a dose of 4 mg/kg. Measurements were performed, and data are presented as means ± SD (n = 6). (C) In vivo biodistribution of free DiR and ex vivo imaging of excised organs and tumor after 24 h post injection of free DiR in K562/DOX tumor-bearing nude mice. 1: brain; 2: kidney; 3: lung; 4: spleen; 5: liver; 6: heart; 7: tumor. (D) In vivo biodistribution of DiR-MTO/βE-SLNs and ex vivo imaging of excised organs and tumor after 24 h post injection of DiR-MTO/βE-SLNs in K562/DOX tumor-bearing nude mice. 1: brain; 2: kidney; 3: lung; 4: spleen; 5: liver; 6: heart; 7: tumor.