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. 2020 Feb 11;12(2):147. doi: 10.3390/pharmaceutics12020147

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Photograph (left) and thermal image (right) of a mouse 24 h after intravenous injection of folic acid conjugated pegylated superparamagnetic iron oxide nanoconjugates (FA-PEG-SPION NCs) under an AC magnetic field with H = 8 kA/m and f = 230 kHz. (b) Tumor-growth behavior and (c) survival period of mice without treatment and treated by intravenous injection of FA-PEG-SPION NCs, application of an alternating current (AC) magnetic field, and application of an AC magnetic field 24 h after intravenous injection of FA-PEG-SPION NCs (n = 5). (d) Photographs of mice 35 days after treatment. The figure was reproduced from [97] after permission from Ivy Spring.