CAT3 |
13a-(S)-3-pivaloyloxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine |
PF403 |
13a-(S)-3-hydroxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine |
GBM |
Glioblastoma multiforme |
TMZ |
Temozolomide |
SLN |
Solid lipid nanoparticles |
MDCK-MDR1 |
Madin-Darby canine kidney cells transfected with the human MDR1 gene |
SD |
Sprague-Dawley |
NMR |
Nuclear magnetic resonance |
TMS |
Tetramethylsilane |
DL |
Drug loading |
EE |
Encapsulation efficiency |
OA |
Oleic acid |
OA-CAT3 |
Oleic acid and CAT3 conjugate |
OA-CAT3-SLN |
OA-CAT3 loaded SLN |
CAT3-SLN |
With the same composition and contents to the OA-CAT3-SLN except the preparation of OA-CAT3 in advance |
DSC |
Differential scanning calorimetry |
FTIR |
Fourier transform infrared spectroscopy |
API |
Active pharmaceutical ingredient |
PVDF |
Polyvinylidene fluoride |
TEER |
Transepithelial electrical resistance |
DI |
Deionized |
PDI |
Polydispersity index |
HBSS |
Hanks’ balanced salt solution |
AP |
Apical side |
BL |
Basolateral |
LC-MS/MS |
Liquid chromatography-mass spectrometry |
P
app
|
Apparent permeability coefficient |
HPLC |
High-performance liquid chromatography |
C6-luc |
Luciferase-expressing C6 cells |
DAPI |
4′,6-diamidino-2-phenylindole |
LSCM |
laser scanning confocal microscopy |
MTT |
3-(4, 5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide |
MCYP |
Methyl-β-Cyclodextrin |
PBS |
Phosphate-buffered saline |
Cou-6 |
Fluorescent Coumarin 6 |
ISTD |
Internal standard |
DAS |
Drug and Statistics |