Table 2.
The pharmacokinetic parameters of CAT3 (as the pro-drug form) in rats after oral administration (n = 6).
| Parameters | CAT3 | OA-CAT3 | CAT3-SLN | OA-CAT3-SLN | |
|---|---|---|---|---|---|
| AUC(0–t) | ng·mL−1·h | 6.39 ± 0.645 ** | 8.632 ± 3.843 * | 3.093 ± 0.133 | 3.284 ± 1.254 |
| AUC(0–∞) | ng·mL−1·h | 7.23 ± 0.476 ** | 8.954 ± 3.716 * | 3.807 ± 0.441 | 4.356 ± 1.562 |
| MRT(0–t) | H | 3.887 ± 0.805 | 5.113 ± 0.616 | 5.433 ± 0.82 | 6.158 ± 0.704 |
| MRT(0–∞) | H | 8.779 ± 6.346 | 6.48 ± 2.444 | 13.954 ± 6.912 | 16.604 ± 2.597 |
| t 1/2z | H | 10.824 ± 6.769 | 4.754 ± 3.951 | 16.742 ± 11.915 | 16.902 ± 1.578 |
| T max | H | 0.167 ± 0 | 0.25 ± 0.129 | 0.153 ± 0.034 | 0.125 ± 0.07 |
| Vz/F | L/kg | 21,169.855 ± 12,087.293 | 8806.657 ± 8572.706 | 62,090.614 ± 42,268.807 | 61,307.763 ± 18,523.656 |
| CLz/F | L/h/kg | 1388.185 ± 91.525 | 1268.605 ± 450.993 | 2653.874 ± 278.551 | 2576.094 ± 1027.274 |
| C max | ng/mL | 6.618 ± 0.942 ** | 2.711 ± 1.201 | 4.539 ± 1.406 ** | 2.245 ± 0.951 |
* p < 0.05, ** p < 0.01 versus OA-CAT3-SLN.