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Effect of different doses of CSP on INH-RIF induced proinflammatory cytokines (a) TNF-α and (b) COX-2. INH-RIF showed steep rise in both the proinflammatory cytokines, administrated with CSP and silymarin decreased TNF-α and COX-2 levels significantly and dose dependently. Values are mean ± S.E.M; n = 6; *** p < 0.001 vs. control, # p < 0.05, ## p < 0.01, ### p < 0.001 vs. group II, n.s stands for not statistically significant.
