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. 2019 Nov 25;62(24):11335–11347. doi: 10.1021/acs.jmedchem.9b01666

Figure 6.

Figure 6

(A) Analogue uptake (6 h, 100 μM) in DU145 cells in the presence and absence of the protein synthesis inhibitor CHX (10 μg/mL). Data are means ± SD, n = 3. *** refers to the statistical significance of p < 0.001 as compared with samples without CHX. (B) ODC activity in DU145 cells treated with 0.1, 10, 25, 50, or 100 μM analogues for 6 h. (C) Induction of OAZ1 protein by the analogues (100 μM) after 4 h of treatment in the presence of MG132 (25 μM), an inhibitor of proteasomal degradation.