Scheme 2. Synthesis of Novel Spermine Analogue 3 from Dinitrile.
Reagents and conditions: (a) 21: CH2=C(CH3)CN, 90 °C. 22: CH3CH=CHCN, 90 °C. (b) Boc2O, THF. (c) LiAlH4, THF, −5 to −2 °C. (d) HCl, EtOH.
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