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. 2020 Jan 29;12(2):90. doi: 10.3390/toxins12020090

Figure 3.

Figure 3

T-2 toxin induced hepatocyte apoptosis via activation of the mitochondria-dependent pathway. (A,B) Intracellular reactive oxygen species (ROS) levels in hepatocytes from chickens treated with T-2 toxin of different concentration at 0, 0.5, 1 and 2 mg/kg. (C) The activity of antioxidant enzymes SOD, CAT, GPX-Sh and MDA content in hepatocytes from chickens treated with T-2 toxin of different concentration at 0, 0.5, 1 and 2 mg/kg. (D) The Bax and Bcl-2 mRNA and protein levels in hepatocytes from chickens treated with T-2 toxin of different concentration at 0, 0.5, 1 and 2 mg/kg. (E) The cytosolic and mitochondrial cyt c level in hepatocytes from chickens treated with T-2 toxin of different concentration at 0, 0.5, 1 and 2 mg/kg. All the data are presented as means ± SEM of three independent experiments. * p < 0.05 and ** p < 0.01, compared with the control group.