Table 3.
Mean hematological parameters for 28 week repeated oral doses of E. kebericho decoction treated rats
| Parameter | Male | Female | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | 150 mg/kg | 300 mg/kg | 600 mg/kg | control | 150 mg/kg | 300 mg/kg | 600 mg/kg | ||
|
WBC × 103 /μL |
6.73 ± 4.20 | 7.31 ± 3.92 | 8.91 ± 1.79 | 8.34 ± 2.62 | 6.62 ± 1.16 | 5.88 ± 3.00 | 5.41 ± 1.98 | 6.60 ± 2.94 | 0.4956/0.8792 |
|
RBC ×106 /μL |
8.80 ± 0.19 | 8.70 ± 0.56 | 8.78 ± 0.42 | 8.91 ± 0.89 | 8.26 ± 0.73 | 7.74 ± 0.38 | 7.93 ± 0.54 | 8.13 ± 0.37 | 0.0194*/0.6137 |
| HGB (g/dl) | 16.14 ± 0.37 | 15.88 ± 0.90 | 16.08 ± 0.60 | 16.46 ± 1.56 | 15.78 ± 1.42 | 15.26 ± 0.25 | 15.42 ± 0.96 | 15.70 ± 0.7280 | 0.5654/0.6188 |
| HCT (%) | 45.74 ± 1.36 | 44.98 ± 2.53 | 46.64 ± 1.86 | 47.64 ± 3.31 | 45.82 ± 3.54 | 44.40 ± 0.98 | 44.06 ± 2.00 | 44.80 ± 2.65 | 0.2559/0.5777 |
| MCV (fL) | 51.96 ± 1.49 | 51.68 ± 0.71 | 53.18 ± 1.73 | 53.50 ± 2.56 | 55.56 ± 1.50 | 56.46 ± 1.12 | 54.26 ± 1.46 | 55.06 ± 1.62 | 0.0023*/0.8887 |
| MCH pg | 18.34 ± 0.30 | 18.25 ± 0.19 | 18.32 ± 0.32 | 18.46 ± 0.45 | 19.10 ± 0.45 | 19.16 ± 0.19 | 19.26 ± 0.57 | 19.30 ± 0.29 | 0.0004*/0.6543 |
| MCHC (g/dL) | 35.28 ± 0.54 | 35.33 ± 0.13 | 34.48 ± 0.73 | 34.48 ± 1.10 | 34.42 ± 0.49 | 33.92 ± 0.54 | 35.44 ± 0.25 | 35.08 ± 0.63 | 0.0143*/0.7061 |
|
PLT ×103 /μL |
1072 ± 90.91 | 993.0 ± 32.37 | 1066 ± 89.12 | 1037 ± 142.9 | 1083 ± 56.89 | 1052 ± 72.99 | 1091 ± 51.52 | 820.6 ± 372.1 | 0.4173/0.2238 |
| RDW-SD(%) | 28.78 ± 0.81 | 29.28 ± 0.93 | 29.82 ± 1.18 | 30.24 ± 0.30 | 29.26 ± 0.94 | 29.32 ± 1.22 | 27.90 ± 1.00 | 28.50 ± 1.39 | 0.0331*/0.7570 |
| RDW-CV (fl) | 19.28 ± 0.23 | 19.40 ± 0.94 | 19.46 ± 0.69 | 19.95 ± 0.74 | 17.96 ± 1.24 | 17.28 ± 0.70 | 17.60 ± 1.11 | 17.60 ± 1.08 | 0.0012*/0.8976 |
| PDW (%) | 8.68 ± 0.22 | 8.52 ± 0.28 | 8.24 ± 0.11 | 8.60 ± 0.26 | 8.22 ± 0.41 | 8.38 ± 0.28 | 8.12 ± 0.22 | 8.28 ± 0.33 | 0.0429*/0.1478 |
|
MPV ×103 /μL |
7.78 ± 0.16 | 7.80 ± 0.14 | 7.64 ± 0.15 | 7.80 ± 0.27 | 7.58 ± 0.22 | 7.74 ± 0.09 | 7.60 ± 0.16 | 7.72 ± 0.23 | 0.3858/0.2674 |
| P-LCR (%) | 9.64 ± 1.01 | 9.72 ± 1.16 | 8.66 ± 0.62 | 9.70 ± 1.70 | 8.26 ± 1.36 | 9.20 ± 0.69 | 8.34 ± 1.18 | 9.12 ± 1.18 | 0.3365/0.2621 |
| PCT (%) | 0.83 ± 0.06 | 0.78 ± 0.02 | 0.81 ± 0.06 | 0.81 ± 0.09 | 0.82 ± 0.04 | 0.81 ± 0.06 | 0.83 ± 0.03 | 0.63 ± 0.28 | 0.5053/0.2593 |
| NEUT (%) | 16.54 ± 1.43 | 22.70 ± 7.31 | 22.03 ± 6.05 | 25.66 ± 7.47 | 17.50 ± 3.37 | 16.64 ± 3.75 | 21.90 ± 7.15 | 17.98 ± 6.54 | 0.1442/0.3017 |
| LYMPH (%) | 77.18 ± 1.63 | 71.18 ± 7.63 | 71.58 ± 6.20 | 67.86 ± 7.63 | 75.84 ± 4.44 | 74.36 ± 4.63 | 74.12 ± 7.43 | 75.58 ± 6.328 | 0.4319/0.3016 |
| MONO (%) | 5.14 ± 1.43 | 4.72 ± 1.79 | 4.65 ± 2.05 | 5.56 ± 0.69 | 5.12 ± 1.43 | 7.52 ± 1.61 | 2.46 ± 1.42 | 3.22 ± 2.87 | 0.0231*/0.0295** |
| EO (%) | 0.86 ± 0.21 | 1.28 ± 0.44 | 1.58 ± 0.15 | 0.78 ± 0.11 | 1.40 ± 0.55 | 1.22 ± 0.37 | 1.24 ± 0.58 | 2.10 ± 2.08 | 0.0346*/0.1318 |
| BASO (%) | 0.28 ± 0.25 | 0.12 ± 0.10 | 0.82 ± 1.44 | 0.14 ± 0.11 | 0.14 ± 0.05 | 0.26 ± 0.32 | 0.08 ± 0.11 | 0.52 ± 0.73 | 0.5610/0.8971 |
| IG (%) | 0.16 ± 0.15 | 0.25 ± 0.17 | 0.17 ± 0.096 | 0.24 ± 0.15 | 0.20 ± 0.19 | 0.08 ± 0.13 | 0.24 ± 0.055 | 0.25 ± 0.21 | 0.6349/0.6137 |
*Significant p-value when males and females are treated separately, ** significant p-value when males and females are grouped together; Where, PLT Platelets, RBC Red blood cells, WBC White blood cells, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration, RDW Red cell distribution width, PDW Platelet volume distribution width, HCT Hematocrit, HGB Hemoglobin