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. 2020 Mar 7;20:77. doi: 10.1186/s12906-020-2865-1

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Germacrone alleviated OGD/R-induced PC12 cells injury by inhibiting autophagy (A) Detection of the LDH release in each group by kit assay (n = 6). (B) Detection of the cell viability of each group by MTT assay (n = 6). (C) Detection of the expression of LC3 in cells of each group by Western Blot (n = 3). (D) Observation of the ultrastructural of PC12 cells without OGD/R injury(a) and after OGD/R 24 h injury(b), as well as the ultrastructural of PC12 cells treated with 20 μM (c), 40 μM (d), 80 μM(e) of germacrone and 3-MA(f) after OGD/R 24 h injury by TEM (× 20,000). Note: ^##P < 0.01, vs control group; ^*P < 0.05, ^**P < 0.01, vs OGD/R group