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. 2020 Mar 7;20:77. doi: 10.1186/s12906-020-2865-1

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The molecular mechanism of germacrone blocked OGD/R-induced autophagy in PC12 cells (A) Compare the effect of treatment with PI3K III inhibitor (3-MA)(a) and PI3K I inhibitor (ZSTK474)(b). Detection of the protein expression of LC3, Beclin-1, PI3K III, Bcl-2, PI3K I, p-Akt and p-mTOR in PC12 cells by Western Blot. (B-H) Quantitative analysis of the gray value of each protein band. Note: n = 3; ^##P < 0.01, vs control group; ^*P < 0.05, ^**P < 0.01, vs OGD/R group. p-Class I PI3K: PI3K I protein; p-Akt: Akt protein; p-mTOR: mTOR protein; Class III PI3K: PI3K III protein