Fig. 2.

Time course of the effect of intrathecal pretreatment with the inhibitor of oxide nitric synthase, L-NAME (a); the selective inhibitor of guanylate cyclase soluble, ODQ (c); and the blocker of ATP sensitive K⁺ channels, glibenclamide (GLB) (e); on the anti-allodynic effect induced by curcumin (CUR) in rats who underwent to L5-L6 spinal nerve ligation (SNL). Data are expressed as mean ± S.E.M. of six animals. The withdrawal threshold was determined 14 days after surgery. The bars show the maximum possible effect (%MPE). *P ≤ 0.05 versus SNL group and ^#P ≤ 0.05 versus Sham group and ^βP ≤ 0.05 versus CUR, determined by one-way ANOVA followed by Tukey test. ^&P ≤ 0.05 versus SNL group and ^ФP ≤ 0.05 versus CUR group was determined by two-way repeated measures analysis of variance followed by the Bonferroni test. Abbreviations: L-NAME: Nω-nitro-L-arginine methyl ester; ODQ: 1H -[1, 2, 4] oxadiazolo [4,3-a]quinoxalin-1-one; SNL: spinal nerve ligation