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. 2020 Mar 14;20:84. doi: 10.1186/s12906-020-2879-8

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — HS-Sultan/ADM, HS-Sultan /VCR, HS-Sultan /DEX, and HS-Sultan /L-PAM cell production and viability with various drugs. a HS-Sultan, HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cells were cultured with the represented concentrations of adriamycin, vincristine, dexamethasone, and melphalan. Cell number was appreciated using a trypan blue dye exclusion assay after 1, 3, 5, or 7 days. Results are notable example of five independent experiments. *p < 0.01 vs. untreated HS-Sultan cells (ANOVA with Dunnett’s test). b HS-Sultan, HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cells were cultured with the represented concentrations of adriamycin, vincristine, dexamethasone, and melphalan for 72 h. Cell viability was appreciated using a trypan blue dye exclusion assay. Results are notable example of five independent experiments. *p < 0.01 vs. control (ANOVA with Dunnett’s test). c Cross-resistance of drug-resistant BL cell lines. HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cells were cultured with 1 μM adriamycin, 10 nM vincristine, 20 μM dexamethasone, or 10 μM melphalan for 72 h. Cell number was detected using a trypan blue dye exclusion assay