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. 2020 Mar 14;20:84. doi: 10.1186/s12906-020-2879-8

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Expression levels of drug resistance-related proteins in HS-Sultan/ADM, HS-Sultan/VCR, HS-Sultan/DEX, and HS-Sultan/L-PAM cells. a Expression levels of a series of efflux pumps and anti-apoptosis proteins were assessed by western blotting analysis. Cytoplasmic cell fractions were extracted and performed to SDS-PAGE/immunoblotting with anti-MDR1, anti-BCRP, anti-MRP1, anti-LRP1, anti-Bcl-2, anti-Bcl-xL, and anti-Survivin antibodies. Anti-β-actin antibodies were used as an internal control. b Quantification of MDR1, BCRP, MRP1, LRP1, Bcl-2, BcL-xL, or Survivin levels, normalized to the amount of the β-actin. Results are notable example of five independent experiments. *p < 0.01 vs. control cells (ANOVA with Dunnett’s test). c mRNA expression of MDR1 and Survivin analyzed by real-time PCR. The results were normalized to GAPDH mRNA levels. Results are notable example of five independent experiments. *p < 0.01 vs. control (ANOVA with Dunnett’s test)