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. 2020 Mar 16;13:17. doi: 10.1186/s13072-020-00338-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Regional expression of DNMT1-dependent genes altered by rotenone. Human DNMT1-dependent genes that were differentially expressed (≥ 1.5-fold change, false-discovery rate FDR ≤ 0.05) in response to rotenone were used for regional expression analysis in the Genotype-Tissue Expression (GTex) database [46]. Brain regions selected are associated with Parkinson’s disease pathogenesis and important for motor function control. The heat map was generated using GTex and organization is clustered by gene function and tissue function. The color of each square indicates the level of expression of the gene in the selected region in transcripts per kilobase million (TPM) represented by the color bar (dark blue = higher expression)