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. 2020 Mar 16;13:17. doi: 10.1186/s13072-020-00338-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Altered CpG methylation at NEFM human DNMT1-dependent locus. a Genomic location of the identified NEFM DNMT1-dependent region. The DNA element and distance from the transcription start site are annotated in black. The transcription factor-binding site for CTCF was annotated from ENCODE v2 and ENCODE Uniform TFBS tracks in Genome Browser. The primer region box indicates the amplified region for Bisulfite-sequencing. b The percent methylation of all CpG sites within the first 200 base-pairs of the amplified region. Delta indicates the change in the mean CpG methylation percentage and the associated false-discovery rate. c The percent methylation of individual CpG sites within the amplified region. Significant differentially methylated cytosines are indicated by * (Δ > 1%; q value < 0.01)