Fig. 2.

Recall proportional to deleterious DMS effect scores. The continuous normalized DMS scores with deleterious effect in SetCommon were split into 20 bins of equal size. a In each bin the fraction of SAVs predicted as having an effect by the binary classification methods (PolyPhen-2 [37], SIFT [39] and SNAP2 [38]) was shown. Naïve Conservation read off PSI-BLAST profiles was treated as an effect prediction when scores were above 0. For all other methods the default score thresholds were applied. b shows the values adjusted for the amount of effect predicted in the first bin