Table 7.

Combination effect of MEVT and AELN with DMA and ATV

Parasite	Drug combination	CI value	Degree of association
B. bovis	MEVT + DMA	1.200	Additive
	AELN + DMA	5.742	Antagonism
	MEVT + ATV	0.209	Synergism
	AELN + ATV	0.822	Synergism
B. bigemina	MEVT + DMA	4.991	Antagonism
	AELN + DMA	3.266	Antagonism
	MEVT + ATV	0.273	Synergism
	AELN + ATV	0.776	Synergism
B. divergens	MEVT + DMA	1.072	Additive
	AELN + DMA	8.667	Antagonism
	MEVT + ATV	0.304	Synergism
	AELN + ATV	1.003	Additive
B. caballi	MEVT + DMA	0.989	Additive
	AELN + DMA	0.947	Additive
	MEVT + ATV	0.291	Synergism
	AELN + ATV	0.392	Synergism
T. equi	MEVT + DMA	0.893	Additive
	AELN + DMA	8.965	Antagonism
	MEVT + ATV	0.844	Synergism
	AELN + ATV	0.999	Additive

MEVT methanolic extract of V. tricolor, AELN acetonic extract of L. nobilis, DMA diminazene aceturate, ATV atovaquone. CI denotes the combination index value