Table 7.
Combination effect of MEVT and AELN with DMA and ATV
| Parasite | Drug combination | CI value | Degree of association |
|---|---|---|---|
| B. bovis | MEVT + DMA | 1.200 | Additive |
| AELN + DMA | 5.742 | Antagonism | |
| MEVT + ATV | 0.209 | Synergism | |
| AELN + ATV | 0.822 | Synergism | |
| B. bigemina | MEVT + DMA | 4.991 | Antagonism |
| AELN + DMA | 3.266 | Antagonism | |
| MEVT + ATV | 0.273 | Synergism | |
| AELN + ATV | 0.776 | Synergism | |
| B. divergens | MEVT + DMA | 1.072 | Additive |
| AELN + DMA | 8.667 | Antagonism | |
| MEVT + ATV | 0.304 | Synergism | |
| AELN + ATV | 1.003 | Additive | |
| B. caballi | MEVT + DMA | 0.989 | Additive |
| AELN + DMA | 0.947 | Additive | |
| MEVT + ATV | 0.291 | Synergism | |
| AELN + ATV | 0.392 | Synergism | |
| T. equi | MEVT + DMA | 0.893 | Additive |
| AELN + DMA | 8.965 | Antagonism | |
| MEVT + ATV | 0.844 | Synergism | |
| AELN + ATV | 0.999 | Additive |
MEVT methanolic extract of V. tricolor, AELN acetonic extract of L. nobilis, DMA diminazene aceturate, ATV atovaquone. CI denotes the combination index value