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. 2020 Mar 10;8:138. doi: 10.3389/fbioe.2020.00138

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Copyright © 2020 Zhang, Gao, Wang, Zhi, Zhang, Guo, Yue, Li, Zhou, Wang, Shen, Wang, Huang and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Function and network analyses of the top prioritized lncRNA in LIHC. (A) LIHC-related GO biological processes enriched for the top 20 lncRNAs identified using CLING. (B) Kaplan–Meier curves of two patient groups with higher (top 50%; n = 100) or lower (bottom 50%; n = 100) expression of MIR22HG in LIHC. Survival days are shown along the X axis and Overall survival rates along the Y axis. (C–F) Subgraphs formed by lncRNA MIR22HG and its directed neighbors associated with LIHC in LCE, lncRNA ceRNA network; LPI, lncRNA–protein interaction network; LMI, lncRNA–miRNA interaction network, and LMCE, lncRNA–mRNA ceRNA network, respectively.