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. 2020 Mar 6;26:e920137-1–e920137-9. doi: 10.12659/MSM.920137

Figure 2.

Figure 2

Gene linkage diagram of the MUC5B gene and the location of the rare variants. Single nucleotide polymorphisms (SNPs) are indicated by amino acid change and position. All the SNPs were confirmed by a minor allele frequency of 0.01 or less. There were 10 variants identified in patients with rheumatoid arthritis and interstitial lung disease (RA-ILD) (A), and four variants were found in patients with RA without ILD (B). Of these variants, eight were restricted to patients with RA-ILD. The red circle indicates the mutant type of SNP. The blue circle indicates the mutant type of insertion-deletion mutation (indel). The different rectangles show the different domains of MUC5B. Orange indicates the trypsin inhibitor-like cysteine-rich (TIL) domain; blue indicates the von Willebrand factor type D domain (vWD); green indicates the C8 domain; yellow indicates the Mucin-2 protein WxxW (PF13330) domain; and red indicates the von Willebrand factor type C (VWC) domain.