Table 1.
Demographical and basic clinical features of the 5 patients
| Case # | Sex | Age (y) | Sample | Underlying diseases | Laboratory test | metagenomics sequencing results and specific reads(n) | |||
|---|---|---|---|---|---|---|---|---|---|
| routine blood test | CRP (mg/L) | PCT (ng/ml) | ESR (mm/h) | ||||||
| 1 | Female | 81 | BALF | hypertension, diabetes, coronary artery diseases | WBC 7.71*10^9, NE% 69.8, NE 5.38*10^9, LN% 17.5↓, LN 1.35*10^9 | 53 | <0.05 | 74 |
Candida albicans (182) Staphylococcus capitis (12) Chlamydia psittaci (6) Human betaherpesvirus 5 (2) |
| 2 | Male | 45 | BALF | diabetes | WBC 8.22*10^9, NE% 93.1↑, NE 7.65*10^9↑, LN% 4.0↓, LN 0.33*10^9↓ | 226 | 1.712 | 42 |
Chlamydia psittaci (225) Lautropia mirabilis (28) Leuconostoc lactis (19) Rothia mucilaginosa (19) Rothia dentocariosa (12) Streptococcus parasanguinis (10) Actinomyces odontolyticus (8) Streptococcus mitis (4) |
| 3 | Female | 85 | Lung tissue | none | WBC 6.38*10^9, NE% 88.9, NE 5.67*10^9, LN% 8.0↓, LN 0.51*10^9 | 184 | 1.64 | 64 | Chlamydia psittaci (48) Staphylococcus epidermidis (1) |
| 4 | Female | 66 | Lung tissue | none | WBC 5.47*10^9, NE% 69.8, NE 3.82*10^9, LN% 19.4↓, LN 1.06*10^9↓ | 124 | 0.13 | 17 | Chlamydia psittaci (205) Corynebacterium striatum (1) Klebsiella pneumoniae (1) |
| 5 | Female | 61 | Lung tissue | none | WBC 6.88*10^9, NE% 68.4, NE 4.70*10^9, LN% 22.7↓, LN 1.56*10^9↓ | 96.7 | <0.05 | 37 | Chlamydia psittaci (2) |
Abbreviations: BALF Bronchoalveolar lavage fluid, CRP C-reactive protein (normal reference range: 0–8 mg/L), ESR Erythrocyte sedimentation rate (normal < 15 mm/h);
LN Lymphocyte, PCT Procalcitonin (normal < 0.05 ng/ml), NE Neutrophil, WBC White blood cell