Table 2.
Comparison of protein sequences SARS-CoV-2 and SARS-CoV by Blastp.
| SARS-CoV-2 | SARS-CoV | |||||
|---|---|---|---|---|---|---|
| Protein Name | Accession Number | Putative Function/Domain | Accession Number | Query Cover * | Percent Identity | |
| 1 | nsp2 | YP_009725298.1 | nonstructural polyprotein pp1a | ABF65834.1 | 100% | 68.34% |
| 2 | nsp3 | YP_009725299.1 | polyprotein orf1a | AFR58698.1 | 100% | 75.82% |
| 3 | nsp4 | YP_009725300.1 | polyprotein 1a | ARO76381.1 | 100% | 80.80% |
| 4 | nsp6 | YP_009725302.1 | nsp6-pp1a/pp1ab (TM3) | NP_828864.1 | 98% | 88.15% |
| 5 | nsp7 | YP_009725303.1 | Chain A, Replicase Polyprotein 1ab, Light Chain | 2AHM_A | 100% | 98.80% |
| 6 | nsp8 | YP_009725304.1 | Chain E, Replicase Polyprotein 1ab, Heavy Chain | 2AHM_E | 100% | 97.47% |
| 7 | nsp9 | YP_009725305.1 | nsp9-pp1a/pp1ab | NP_828867.1 | 100% | 97.35% |
| 8 | nsp10 | YP_009725306.1 | Chain A, Non-structural Protein 10 | 5C8S_A | 100% | 97.12% |
| 9 | nsp11 | YP_009725312.1 | nsp11-pp1a | NP_904321.1 | 100% | 84.62% |
| 10 | orf1a polyprotein | YP_009725295.1 | orf1a polyprotein (pp1a) | NP_828850.1 | 100% | 80.58% |
| 11 | orf1ab polyprotein | YP_009724389.1 | orf1ab polyprotein (pp1ab) | NP_828849.2 | 100% | 86.26% |
| 12 | orf3a protein | YP_009724391.1 | hypothetical protein sars3a | NP_828852.2 | 100% | 72.04% |
| 13 | orf6 protein | YP_009724394.1 | hypothetical protein sars6 | NP_828856.1 | 100% | 68.85% |
| 14 | orf7a protein | YP_009724395.1 | protein 8 | ARO76387.1 | 100% | 87.70% |
| 15 | orf7b protein | YP_009725296.1 | hypothetical protein sars7b | NP_849175.1 | 95% | 85.37% |
| 16 | orf8 protein | YP_009724396.1 | - | - | - | - |
| 17 | orf10 protein | YP_009725255.1 | - | - | - | - |
| 18 | 2’-O-ribose methyltransferase | YP_009725311.1 | nsp16-pp1ab (2’-o-MT) | NP_828873.2 | 99% | 93.60% |
| 19 | 3C-like proteinase | YP_009725301.1 | polyprotein 1a | ARO76381.1 | 100% | 96.08% |
| 20 | 3’-to-5’ exonuclease | YP_009725309.1 | nsp14-pp1ab (nuclease ExoN homolog) | NP_828871.1 | 100% | 95.07% |
| 21 | endoRNAse | YP_009725310.1 | nsp15-pp1ab (endoRNAse) | NP_828872.1 | 100% | 88.73% |
| 22 | envelope protein | YP_009724392.1 | E protein | APO40581.1 | 100% | 94.74% |
| 23 | helicase | YP_009725308.1 | nsp13-pp1ab (ZD, NTPase/HEL) | NP_828870.1 | 100% | 99.83% |
| 24 | leader protein | YP_009725297.1 | nsp1-pp1a/pp1ab | NP_828860.2 | 100% | 84.44% |
| 25 | membrane glycoprotein | YP_009724393.1 | matrix protein | NP_828855.1 | 100% | 90.54% |
| 26 | nucleocapsid phosphoprotein | YP_009724397.2 | nucleocapsid protein | ARO76389.1 | 100% | 90.52% |
| 27 | RNA-dependent RNA polymerase | YP_009725307.1 | nsp12-pp1ab (RdRp) | NP_828869.1 | 100% | 96.35% |
| 28 | surface glycoprotein | YP_009724390.1 | spike glycoprotein | ABD72985.1 | 100% | 76.42% |
“-” represents no homologous protein. Query cover represents the percentage of the protein sequences that are participating in the comparison. Percent identity indicates the homology.