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. 2020 Feb 9;12(2):191. doi: 10.3390/v12020191

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Epigenetic changes driven by Ro5-3335, Alprazolam, and Clonazepam. ChIP was performed to test the effect of Alprazolam and Clonazepam on occupancy of the HIV-1 LTR. TZMbl cells were treated with 10 μM Ro5-3335, Alprazolam, or Clonazepam in the presence or absence of 5 μM SAHA. ChIP was performed using antibodies against (A) H3K9ac, (B) STAT5, and (C) CBP/P300. Primers against HIV U3 LTR were used for qPCR. * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001. Ro5: Ro5-3335, Alp: alprazolam, Clon: clonazepam.