Skip to main content
. 2020 Jan 29;12(2):154. doi: 10.3390/v12020154

Table 2.

The overview of alkaloids with anti-HSV activity.

Compound Antiherpetic and Cytotoxicity Assays, Strains, Cells, and Reference Agents Results Additional Information Source
Harmine (59) Vero cells, HSV-2
PRA
ACV CC50 and IC50 > 3.000 mg/mL and 0.1 μg/mL, respectively, SI > 30.000
CC50 and IC50 12.5 μg/mL and 0.3 μg/mL, respectively, SI = 41.6 Peganum harmala, Banisteriopsis caapi, Passiflora incarnata [54]
Human foreskin fibroblasts (HFF), HSV-1 (166vVP22-GFP)
GFP-based reporter assay
Cidofovir at 3 μM reduced to 20%
At 3.3 μM, 59 reduced HSV-1 replication to approx. 50%, at 10 μM to approx. 5% 59 inhibited viral protein expressed as a dual-specificity tyrosine phosphorylation-regulated kinase inhibitor. [55]
Harmane (60) Vero cells, HSV-1, HSV-2
PRA
ACV HSV-1 EC50 0.8 μg/mL
HSV-1 EC50 4.9 μg/mL, SI = 11.8
HSV-2 EC50 71.8 μg/mL, SI = 24.7
P. harmala, B. caapi, P. incarnata [51]
Aaptamine (61) (8,9-dimethoxy-1H-benzo[d,e][1,6]-naphthyridin) Vero cells, HSV-1
CPE
EC50 7.0 µg/mL Marine sponge Aaptos spp. [56]