Table 2.

The overview of alkaloids with anti-HSV activity.

Compound	Antiherpetic and Cytotoxicity Assays, Strains, Cells, and Reference Agents	Results	Additional Information	Source
Harmine (59)	Vero cells, HSV-2 PRA ACV CC50 and IC50 > 3.000 mg/mL and 0.1 μg/mL, respectively, SI > 30.000	CC50 and IC50 12.5 μg/mL and 0.3 μg/mL, respectively, SI = 41.6	Peganum harmala, Banisteriopsis caapi, Passiflora incarnata	[54]
	Human foreskin fibroblasts (HFF), HSV-1 (166vVP22-GFP) GFP-based reporter assay Cidofovir at 3 μM reduced to 20%	At 3.3 μM, 59 reduced HSV-1 replication to approx. 50%, at 10 μM to approx. 5%	59 inhibited viral protein expressed as a dual-specificity tyrosine phosphorylation-regulated kinase inhibitor.	[55]
Harmane (60)	Vero cells, HSV-1, HSV-2 PRA ACV HSV-1 EC50 0.8 μg/mL	HSV-1 EC50 4.9 μg/mL, SI = 11.8 HSV-2 EC50 71.8 μg/mL, SI = 24.7	P. harmala, B. caapi, P. incarnata	[51]
Aaptamine (61) (8,9-dimethoxy-1H-benzo[d,e][1,6]-naphthyridin)	Vero cells, HSV-1 CPE	EC50 7.0 µg/mL	Marine sponge Aaptos spp.	[56]