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. 2020 Mar 10;11:353. doi: 10.3389/fimmu.2020.00353

FIGURE 1.

FIGURE 1

LXR agonists induce a proinflammatory phenotype in human monocytes. Monocytes were treated as indicated with BCG, 2 μM T1317 (LXR agonist), 10 μM GW3965 (LXR agonist), 5 μM GSK2033 (LXR antagonist) or vehicle for 24 h, kept for 5 days in complete medium and restimulated with 5 μg/ml Pam3cys or 10 ng/ml LPS for 24 h. IL-6 (A,D,E), TNFα (B,F) and IL-8 (C) were measured in the supernatant. Graphs represent mean values ± SD of six individuals in three different experiments. *P < 0.05, **P < 0.01, and ***P < 0.001.