Figure 7.

The effect of quercetin on pro‐inflammatory factors (IL‐1β, TNF‐α, IL‐6) by immunohistochemistry (A‐L). We found that Ti significantly promoted the release of pro‐inflammatory factors. The production of the pro‐inflammatory factor was significantly reduced after quercetin treatment. We further made the immunofluorescence of OPG/RANKL. We found that Ti significantly promoted the high expression of the RANKL. However, the RANKL expression was significantly inhibited, but OPG protein expression increased with addition to the quercetin (M‐T)