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. 2020 Jan 23;24(5):2832–2846. doi: 10.1111/jcmm.14834

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© 2020 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A, Images representing the scoring system ranging from 1 (best) to 3 (worst), depending upon the cristae appearance. B, Representative electron micrographs showing mitochondria (white arrows) observed in (a & b) pre– and post–metformin‐treated patients, (c & d) pre– and post–voglibose‐treated patients and (e & f) pre– and post–placebo‐treated patients. Scale bars are indicated. Original magnification: A to E, 5000×, (C). Table depicting the mitochondrial morphological characteristics and (D) scatter plot with bar diagram displaying the percentage of damaged mitochondria in patients with NDT2DM at baseline and post‐follow‐up. Values are expressed in Mean ± SD (n = 3 each group). *P < .05 vs baseline