Table 1.

Phenotypic and biochemical characteristics of Ins²⁺/Akita, ApoE^−/− and Ins²⁺/Akita:ApoE^−/− mice

	C57/BL6 control	Ins2+/Akita	ApoE−/−	Ins2+/Akita:ApoE−/−
Bodyweight, g	30 ± 0.5	22 ± 0.3	35 ± 0.7	26 ± 0.5
Fasted plasma glucose, mg/dL	110 ± 10	350 ± 20*	150 ± 15	390 ± 25*
Fasted plasma total cholesterol, mg/dL	105 ± 5	125 ± 8	425 ± 25*	625 ± 15*, §
Fasted plasma triglyceride, mg/dL	89 ± 7	105 ± 5	95 ± 6	103 ± 10

Data shown are mean ± SD (n = 7 mice/group). To determine plasma glucose and lipid levels, tail blood samples were collected from each group of mice under fasting conditions.

Abbreviation: ApoE, apolipoprotein E.

^* P < .05 vs C57/BL6 control mice.

^§ P < .05 vs ApoE^−/− mice.