Figure 4.

HMGA2 is the target gene of let‐7g‐5p. A, binding sites between HMGA2 and let‐7g‐5p; B, luciferase activity of the HMGA2‐Wt and HMGA2‐Mut after transfection; C, HMGA2 mRNA enrichment of bio‐let‐7g‐5p‐wt and bio‐let‐7g‐5p‐mut; ^* P < .05 vs the NC mimic group; ^# P < .05 vs the bio‐probe NC group. All measurement data were summarized as mean ± SD. Comparisons among multiple groups were performed with one‐way analysis of variance. The experiment was repeated three times independently. HMGA2, high mobility group A2; NC, negative control; wt, wild‐type; mut, mutant; 3′UTR, 3′ untranslated region