Figure 8.

VB represses tumour growth of GBM cells by up‐regulation of let‐7g‐5p in vivo. A, xenograft tumours in nude mice injected with U87 cells in each group; B, xenograft tumours in nude mice injected with U251 cells in each group; C, changes of tumour volume in nude mice injected with U87 cells at 1, 2, 3, and 4 w; D, changes of tumour volume in nude mice injected with U251 cells at 1, 2, 3 and 4 w; E, let‐7g‐5p expression in nude mice injected with U87 cells in each group by RT‐qPCR; F, let‐7g‐5p expression in nude mice injected with U251 cells in each group by RT‐qPCR; G, expression of LC3 II/I and Beclin1 after U87 tumorigenesis in each group measured by Western blot; H, expression of LC3 II/I and Beclin1 after U251 tumorigenesis in each group measured by Western blot.^* P < .05 vs the blank group and the NC group; ^& P < .05 vs the NC mimic group; ^# P < .05 vs the NC inhibitor group. All measurement data were summarized as mean ± SD. Comparisons among multiple groups were performed with one‐way analysis of variance. The experiment was repeated three times independently