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. 2020 Feb 13;12(2):443. doi: 10.3390/polym12020443

Figure 4.

Figure 4

p47phox siRNA-encapsulated PLGA NPs reduced chondrocyte cell death by decreasing ROS production in OA rats. (A) On day 3 after MIA-induced OA, p47phox siRNA-loaded NPs were directly administered to the knee via intra-articular injections, and von Frey filament tests were performed on days 7, 10, and 14 after injection; all data are presented as the mean ± standard error of the mean. (B) Representative hematoxylin-stained sections of knee joints from rats with MIA-induced OA after 14 days, scale bar = 50 μm. (C) Cell viability over time in human primary chondrocytes following MIA injection. (D) DHE fluorescence imaging of knees in the OA rat model at 1 week after injection of PLGA NPs; white lines indicate cartilage in the tissue, scale bar = 50 μm. (E) Density of fluorescence intensity showing ROS production; all data represent the mean ± standard error of the mean (error bars) of three experiments.