Table 3.
Microparticles | Powder Emitted Dose (%) | Drug | MMAD (µm) | GSD (µm) | FPD (mg) | FPF (%) |
---|---|---|---|---|---|---|
ChS/INH/RFB (ethanol) | 90.9 ± 1.0a | INH | 3.8 ± 0.1b | 1.9 ± 0.1c | 3.1 ± 0.3d | 43.7 ± 2.4g |
RFB | 3.9 ± 0.1 b | 2.0 ± 0.1c | 1.5 ± 0.1e | 42.6 ± 1.7g | ||
ChS/INH/RFB (HCl) | 89.6 ± 1.8a | INH | 4.0 ± 0.2 b | 2.0 ± 0.0c | 2.9 ± 0.1d | 35.0 ± 1.7h |
RFB | 4.0 ± 0.3 b | 2.1 ± 0.1c | 1.2 ± 0.1f | 34.0 ± 3.7h |
FPD: fine particle dose; FPF: fine particle fraction; GSD: geometric standard deviation; MMAD: mass median aerodynamic diameter.