Table 1. Association between sLOX-1 and disease duration, serological and clinical features.
| Observation | Low LOX-1 (n) | Low | High LOX-1 (n) | High | P value (Group comparison) | Spearman Correlation (rs) | P value (rs) |
|---|---|---|---|---|---|---|---|
| LOX-1 (Median (IQR)/%) | LOX-1 (Median (IQR)/%) | ||||||
| Age (yrs) | 170 | 45 (36–53) | 103 | 37(28–49) | 8.50E-03 | -0.17 | 5.80E-03 |
| Disease Duration (yrs) | 170 | 10(5–19) | 103 | 11(5–22) | 0.2 | 0.03 | 0.61 |
| Age at 1st Diagnosis | 170 | 32 (23–41) | 103 | 23(21–31) | <0.0001 | -0.26 | <0.0001 |
| C3 (mg/dL) | 170 | 94.8 (80.9–108.7) | 103 | 109 (91.8–131) | 4.80E-07 | 0.36 | 1.30E-09 |
| C4 (mg/dL) | 169 | 18.4 (12.6–23.6) | 103 | 22 (15.4–25.2) | 4.98E-03 | 0.22 | 2.09E-04 |
| Platelets (# per μl WB) | 170 | 224.5 (182–270) | 103 | 243 (202–300) | 0.02 | 0.19 | 1.32E-03 |
| ESR (mm/hr) | 168 | 19 (11.5–38) | 102 | 21 (12.5–34) | 0.74 | -0.05 | 0.4 |
| WBC (k/μl) | 170 | 4.7 (3.8–6.1) | 103 | 6 (4.7–8.0) | 0.67 | 0.36 | 9.01E-10 |
| SLEDAI | 169 | 2 | 102 | 0 | 3.30E-03 | -0.25 | 3.11E-05 |
| Discoid Rash | 170 | 2.94% | 103 | 0% | 0.16 | ||
| Malar Rash | 169 | 12.43% | 103 | 7.77% | 0.31 | ||
| Rash | 169 | 13.61% | 102 | 8.82% | 0.33 | ||
| Secondary Sjogren's | 170 | 17.06% | 103 | 12.62% | 0.39 | ||
| Arthritis | 169 | 5.92% | 102 | 8.82% | 0.46 | ||
| Active Nephritis | 170 | 12.94% | 103 | 9.71% | 0.56 | ||
| Hematuria | 169 | 1.18% | 102 | 3.92% | 0.2 | ||
| Proteinuria | 169 | 4.73% | 102 | 3.92% | 1 | ||
| Pyuria | 169 | 2.96% | 102 | 6.86% | 0.14 | ||
| Alopecia | 169 | 10.06% | 102 | 0.98% | 2.27E-03 | ||
| Thrombocytopenia | 169 | 3.55% | 102 | 0% | 0.09 | ||
| Low Complement | 169 | 43.79% | 102 | 19.61% | 4.30E-05 | ||
| Leukopenia | 169 | 6.51% | 102 | 0.98% | 0.03 | ||
| Anti-nuclear antibodies (ANA) | 169 | 98.22% | 103 | 94.17% | 0.09 | ||
| Lupus anti-coagulant (LAC) | 160 | 31.88% | 91 | 34.07% | 0.78 | ||
| Anti-ds DNA | 170 | 69.41% | 103 | 66.99% | 0.69 | ||
| Anti-Extractable nuclear Ags | 168 | 88.69% | 103 | 68.93% | 9.46E-05 |
Represented p-values for comparison between groups. Spearman correlations (rs) and their p- value calculated for association of groups containing continuous variables with corresponding sLOX-1 levels. C3 = Complement 3, C4 = Complement 4, ESR = Erythrocyte sedimentation rate, WBC = White blood cells, SLEDAI = SLE Disease Activity Index.