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. 2020 Mar 17;15(3):e0230290. doi: 10.1371/journal.pone.0230290

Table 1. Patients’ and treatment characteristics for overall group and matched group after propensity scoring.

Variables Overall Patients Matched Patients
Propofol (n = 266) Desflurane (n = 365) p value Propofol (n = 264) Desflurane (n = 264) p value SMD
Time since the earliest included patient (years), Mean (SD) 4.8 (2.4) 5.3 (3.0) 0.014 4.8 (2.4) 4.3 (2.5) 0.045 0.177
Calendar period, n (%) <0.001 0.080 0.133
 2009–12 92 (35) 125 (34) 92 (35) 116 (44)
 2013–15 110 (41) 97 (27) 110 (42) 89 (34)
 2016–18 64 (24) 143 (39) 62 (24) 59 (22)
Age (yr), mean (SD) 65.3 (6.5) 66.4 (7.2) 0.066 65.3 (6.5) 66.3 (7.4) 0.118 0.136
PSA 0.604 0.254 0.119
 ≤ 10 143 (54) 205 (56) 141 (53) 155 (59)
 > 10 123 (46) 160 (44) 123 (47) 109 (41)
Charlson comorbidity index, mean (SD) 4.1 (0.70) 4.2 (0.78) 0.164 4.1 (0.70) 4.2 (0.79) 0.242 0.108
Functional status, n (%) 0.232 0.549 0.131
 < 4 METs 22 (8) 42 (12) 22 (8) 27 (10)
 ≥ 4 METs 244 (92) 323 (89) 242 (92) 234 (90)
ASA, n (%) 0.232 0.549 0.131
 Lower risk 244 (92) 323 (89) 242 (92) 234 (90)
 Higher risk 22 (8) 42 (12) 22 (8) 27 (10)
TNM stage of primary tumor, n (%) 0.563 0.045 0.173
 I 44 (17) 65 (18) 43 (16) 51 (19)
 II 197 (75) 274 (75) 196 (74) 202 (77)
 III 25 (9) 26 (7) 25 (10) 11 (4)
Tumor grade (Gleason grade) 0.145 0.178 0.011
 Low risk (Gleason grade ≤ 6) 36 (14) 45 (12) 34 (13) 24 (9)
 Medium risk (Gleason = 7) 101 (38) 167 (46) 101 (38) 119 (45)
 High risk (Gleason > 7) 129 (49) 153 (42) 129 (49) 121 (46)
Tumor size (cm), mean (SD) 1.6 (0.89) 1.5 (0.83) 0.169 1.6 (0.89) 1.6 (0.87) 0.419 N/A
Intraoperative blood transfusion, n (%) 10 (4) 8 (2) 0.354 10 (4) 6 (2) 0.446 N/A
Grade of surgical complications, n (%) 0.975 1.000 N/A
 0 257 (97) 354 (97) 255 (97) 256 (97)
 I + II 9 (3) 11 (3) 9 (3) 8 (3)
Postoperative radiation therapy, yes, n (%) 32 (12) 50 (14) 0.620 32 (12) 34 (13) 0.895 N/A
Postoperative ADT, yes, n (%) 42 (16) 55 (15) 0.892 42 (16) 46 (17) 0.726 N/A
Postoperative biochemical recurrence, n (%) 2 (1) 13 (4) 0.043 2 (1) 12 (5) 0.015 N/A
All-cause mortality, n (%) 2 (1) 24 (7) 0.001 2 (1) 21 (8) <0.001 N/A
Cancer mortality, n (%) 0 (0) 5 (1) 0.073 0 (0) 4 (2) 0.055 N/A

PSA: prostate specific antigen; METs: Metabolic equivalents; ASA: American Society of Anesthesiologists; TNM: tumor-node-metastasis; ADT: androgen deprivation therapy; SMD: standardized mean differences; N/A: not applicable.