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. 2020 Mar 16;2020(3):CD011154. doi: 10.1002/14651858.CD011154.pub2

NCT00624676.

Methods Study design: parallel, single‐blind design; 80 participants in total
Duration of follow‐up: 12 weeks
Participants Inclusion criteria
  • 18 years of age or older

  • Phototype > grade I

  • Facial inflammatory acne with 15 to 50 inflammatory lesions and fewer than 50 non‐inflammatory lesions


Exclusion criteria
  • Pregnant, nursing, or not using any efficient contraception

  • History of major medical or psychiatric condition or surgical interventions, history of photosensitivity

  • Acute or chronic disease or dermatological condition on the face other than acne

  • Allergy to one of the constituents of the study product

  • Using topical acne treatment, cyclins, or zinc‐based treatment, or oral isotretinoin


Sites of acne: face
Interventions Interventions in Group A
  • Topical treatment: lipo hydroxy acid

  • Regimen: leave‐on

  • Concentration: 0.3%

  • Vehicle: gel

  • Dose: twice daily

  • Duration: 12 weeks


Interventions in Group B
  • Topical treatment: benzoyl peroxide

  • Regimen: leave‐on

  • Concentration: 5%

  • Vehicle: gel

  • Dose: once daily

  • Duration: 12 weeks

Outcomes Primary outcomes of review interest
  • None


Secondary outcomes of review interest
  • Investigator‐assessed change in lesion counts.


Other outcomes reported in the study
  • Number of events of pruritus, burning, tingling, erythema, and desquamation

Notes This trial has been completed and is likely eligible for our review. We attempted to contact the principal investigator, Robert Bissonnette (rbissonnette@innovaderm.ca), with enquiry about availability of the full text but were unsuccessful