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. 2020 Mar 17;15(3):e0229465. doi: 10.1371/journal.pone.0229465

Table 3. Sex-stratified multivariable sequentially adjusted cox proportional hazard models for demographic, socioeconomic, health behavioural, and number of chronic comorbidities and of index prospective ACSC hospitalization for pooled study participants from CCHS cycles 2000/2001-2011 followed from time of interview to index ACSC hospitalization, death, or end of study (March 31, 2013) (n = 318,845).

MALES
MODEL 1 MODEL 2 MODEL 3 MODEL 4 MODEL 5
AGE-ADJUSTED1 AGE-ADJUSTED DEMOGRAPHICS2 MODEL 2 + SES3 MODEL 3 + BEHAVIOURS4 MODEL 4 + CHRONIC MORBIDITIES5
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
DEMOGRAPHICS
Self-identified Ethnicity
White 1.00 1.00 1.00 1.00 1.00
Visible minorities 0.74 (0.60, 0.91) 0.77 (0.63, 0.94) 0.83 (0.66, 1.06) 0.87 (0.69, 1.11) 0.90 (0.72, 1.14)
Urban/Rural
Urban 1.00 1.00 1.00 1.00 1.00
Rural 1.32 (1.19, 1.46) 1.26 (1.14, 1.39) 1.18 (1.07, 1.31) 1.13 (1.01, 1.26) 1.13 (1.01, 1.26)
SES
Marital Status
Single 1.22 (1.02, 1.44) 0.95 (0.80, 1.13) 0.92 (0.77, 1.09) 0.90 (0.76, 1.07)
Married or common-law 1.00 1.00 1.00 1.00
Separated or divorced 1.51 (1.32, 1.74) 1.25 (1.08, 1.44) 1.12 (0.96, 1.31) 1.02 (0.86, 1.20)
Widowed 1.76 (1.35, 2.29) 1.44 (1.09, 1.89) 1.41 (1.04, 1.90) 1.45 (1.08, 1.94)
Immigrant Status
Canada-born 1.00 1.00 1.00 1.00
Immigrant 0.64 (0.54, 0.75) 0.67 (0.56, 0.79) 0.77 (0.65, 0.92) 0.83 (0.69, 0.98)
Household National Income Quintile6
Lowest 2.71 (2.27, 3.24) 2.82 (2.30, 3.46) 2.08 (1.66, 2.62) 1.58 (1.25, 2.00)
Lower-middle 1.94 (1.60, 2.35) 2.05 (1.68, 2.51) 1.68 (1.36, 2.07) 1.47 (1.19, 1.81)
Middle 1.34 (1.11, 1.61) 1.39 (1.15, 1.69) 1.21 (0.98, 1.49) 1.11 (0.90, 1.36)
Upper-middle 1.23 (1.01, 1.48) 1.28 (1.05, 1.55) 1.21 (0.98, 1.49) 1.17 (0.95, 1.44)
Highest 1.00 1.00 1.00 1.00
Household Education
Less than secondary 2.06 (1.80, 2.35) 1.43 (1.24, 1.65) 1.20 (1.02, 1.41) 1.16 (0.99, 1.37)
Secondary completed 1.31 (1.12, 1.53) 1.12 (0.95, 1.31) 1.10 (0.92, 1.31) 1.14 (0.96, 1.37)
Some post-secondary 1.43 (1.18, 1.72) 1.21 (1.00, 1.46) 1.12 (0.92, 1.37) 1.11 (0.91, 1.36)
Post-secondary completed 1.00 1.00 1.00 1.00
BEHAVIOURAL
Smoking
Heavy smoker 3.73 (3.12, 4.47) 3.13 (2.57, 3.81) 2.65 (2.17, 3.23)
Light smoker 2.41 (2.04, 2.84) 2.20 (1.84, 2.64) 1.99 (1.66, 2.38)
Former heavy 2.01 (1.70, 2.39) 1.88 (1.57, 2.26) 1.60 (1.33, 1.92)
Former light 1.32 (1.11, 1.57) 1.36 (1.13, 1.64) 1.25 (1.04, 1.51)
Never 1.00 1.00 1.00
Alcohol Consumption
Heavy 1.12 (0.88, 1.41) 0.78 (0.62, 0.99) 0.77 (0.61, 0.98)
Moderate 0.87 (0.71, 1.07) 0.85 (0.69, 1.05) 0.87 (0.71, 1.07)
Light 1.00 1.00 1.00
Never 1.66 (1.39, 1.98) 1.33 (1.11, 1.60) 1.22 (1.02, 1.47)
Corrected BMI
Obese 1.69 (1.44, 1.98) 1.59 (1.33, 1.90) 1.28 (1.06, 1.54)
Over weight 0.95 (0.81, 1.10) 1.02 (0.86, 1.22) 0.96 (0.81, 1.14)
Normal weight 1.00 1.00 1.00
Under weight 2.72 (1.73, 4.30) 2.27 (1.35, 3.83) 1.98 (1.14, 3.43)
Physical Activity
Inactive 1.83 (1.60, 2.10) 1.37 (1.19, 1.59) 1.28 (1.10, 1.48)
Moderate 1.30 (1.10, 1.53) 1.24 (1.04, 1.49) 1.20 (1.00, 1.43)
Active 1.00 1.00 1.00
HEALTH STATUS
Number of Chronic Morbidities 1.49 (1.46, 1.53) 1.37 (1.33, 1.41)
FEMALES
MODEL 1 MODEL 2 MODEL 3 MODEL 4 MODEL 5
AGE-ADJUSTED1 AGE-ADJUSTED DEMOGRAPHICS2 MODEL 2 + SES3 MODEL 3 + BEHAVIOURS4 MODEL 4 + CHRONIC MORBIDITIES5
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
DEMOGRAPHICS
Self-identified Ethnicity
White 1.00 1.00 1.00 1.00 1.00
Visible minorities 0.81 (0.62, 1.07) 0.84 (0.64, 1.10) 1.02 (0.78, 1.34) 1.09 (0.83, 1.44) 1.08 (0.82, 1.42)
Urban/Rural
Urban 1.00 1.00 1.00 1.00 1.00
Rural 1.24 (1.11, 1.38) 1.20 (1.08, 1.33) 1.18 (1.05, 1.31) 1.12 (1.00, 1.26) 1.15 (1.03, 1.29)
SES
Marital Status
Single 1.27 (1.00, 1.62) 1.08 (0.85, 1.37) 1.05 (0.82, 1.35) 0.99 (0.7, 1.27)
Married or common-law 1.00 1.00 1.00 1.00
Separated or divorced 1.71 (1.48, 1.98) 1.28 (1.09, 1.51) 1.13 (0.95, 1.34) 1.01 (0.84, 1.21)
Widowed 1.70 (1.46, 1.97) 1.26 (1.08, 1.47) 1.18 (1.00, 1.39) 1.14 (0.96, 1.34)
Immigrant Status
Canada-born 1.00 1.00 1.00 1.00
Immigrant 0.52 (0.42, 0.65) 0.50 (0.41, 0.61) 0.64 (0.53, 0.78) 0.69 (0.57, 0.84)
Household National Income Quintile6
Lowest 3.51 (2.86, 4.31) 3.12 (2.50, 3.89) 2.02 (1.61, 2.53) 1.52 (1.22, 1.91)
Lower-middle 2.42 (1.89, 3.09) 2.27 (1.76, 2.93) 1.70 (1.31, 2.21) 1.53 (1.18, 1.99)
Middle 1.41 (1.12, 1.77) 1.35 (1.08, 1.70) 1.09 (0.87, 1.37) 1.04 (0.83, 1.30)
Upper-middle 1.51 (1.17, 1.94) 1.51 (1.17, 1.95) 1.35 (1.03, 1.76) 1.31 (1.00, 1.72)
Highest 1.00 1.00 1.00 1.00
Household Education
Less than secondary 2.55 (2.21, 2.94) 1.75 (1.51, 2.02) 1.36 (1.18, 1.55) 1.30 (1.13, 1.48)
Secondary completed 1.40 (1.20, 1.65) 1.16 (0.99, 1.36) 1.04 (0.88, 1.22) 1.09 (0.92, 1.28)
Some post-secondary 1.77 (1.40, 2.25) 1.45 (1.15, 1.84) 1.29 (1.00, 1.67) 1.29 (1.00, 1.66)
Post-secondary completed 1.00 1.00 1.00 1.00
BEHAVIOURAL
Smoking
Heavy smoker 6.66 (5.51, 8.05) 4.62 (3.85, 5.55) 3.41 (2.81, 4.13)
Light smoker 3.52 (2.98, 4.16) 3.00 (2.57, 3.51) 2.66 (2.27, 3.11)
Former heavy 2.84 (2.30, 3.51) 2.32 (1.87, 2.87) 1.93 (1.55, 2.40)
Former light 1.63 (1.35, 1.96) 1.66 (1.38, 1.98) 1.52 (1.27, 1.82)
Never 1.00 1.00 1.00
Alcohol Consumption
Heavy 2.67 (1.77, 4.02) 1.47 (0.97, 2.23) 1.47 (0.97, 2.22)
Moderate 0.96 (0.71, 1.31) 0.93 (0.68, 1.27) 0.94 (0.69, 1.28)
Light 1.00 1.00 1.00
Never 2.28 (1.75, 2.98) 1.84 (1.41, 2.41) 1.67 (1.27, 2.19)
Corrected BMI
Obese 1.87 (1.61, 2.17) 1.47 (1.24, 1.75) 1.13 (0.95, 1.35)
Over weight 1.02 (0.89, 1.17) 0.96 (0.82, 1.11) 0.89 (0.77, 1.03)
Normal weight 1.00 1.00 1.00
Under weight 3.86 (2.30, 6.48) 2.99 (1.72, 5.18) 2.78 (1.61, 4.81)
Physical Activity
Inactive 1.75 (1.50, 2.03) 1.22 (1.04, 1.42) 1.11 (0.95, 1.30)
Moderate 1.00 (0.82, 1.24) 0.90 (0.72, 1.11) 0.88 (0.72, 1.09)
Active 1.00 1.00 1.00
HEALTH STATUS
Number of Chronic Morbidities 1.48 (1.44, 1.51) 1.35 (1.31, 1.38)

1Model 1 is age- and cycle-adjusted univariate analysis of independent variables.

2Model 2 is age- and cycle-adjusted analysis of race and rurality variables.

3Model 3 is age- and cycle-adjusted analysis of race, rurality, marital status, immigrant status, national household income quintiles, and highest level of household educational attainment.

4Model 4 is age- and cycle-adjusted analysis of race, rurality, marital status, immigrant status, national household income quintiles, highest level of household educational attainment, smoking status, alcohol consumption, BMI, and physical activity levels.

5Model 5 is age- and cycle-adjusted analysis of race, rurality, marital status, immigrant status, national household income quintiles, highest level of household educational attainment, smoking status, alcohol consumption, BMI, physical activity levels, and number of chronic morbidities.

6 Unknown income was modelled as a separate categorical level.