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Diagram for mediation of postmortem R2 clusters (C1, C2) on association between AK4 and cognitive decline. (a) The effects estimated with demographic variables as covariates are shown. (b) The effects estimated with AD and common neuropathology added to the covariates in (a) are shown. C1 and C2 are mean of the R2 measurements from cluster groups that are associated with AK4.
