Table 2c.
Protein | Cluster group1 | Cluster group2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Beta | se | P | Beta | se | P | Beta | se | P | |||
AK4 | Direct effect | −0.0094 | 0.0035 | 0.0074 | 0.0206 | 0.0037 | <0.0001 | −0.0112 | 0.0035 | 0.0014 | |
Indirect Effect | through C1 | −0.0032 | 0.0011 | 0.0036 | |||||||
Indirect Effect | through C2 | −0.0019 | 0.0008 | 0.0175 | |||||||
ITPK1 | Direct effect | 0.0075 | 0.0036 | 0.0362 | 0.0147 | 0.0038 | 0.0001 | - | - | - | |
Indirect Effect | through C1 | 0.0025 | 0.0009 | 0.0077 | |||||||
IGFBP5 | Direct effect | −0.0142 | 0.0035 | <0.0001 | 0.0185 | 0.0038 | <0.0001 | −0.0166 | 0.0036 | <0.0001 | |
Indirect Effect | through C1 | −0.0029 | 0.0010 | 0.0037 | |||||||
Indirect Effect | through C2 | −0.0031 | 0.0010 | 0.0019 | |||||||
HSPB2 | Direct effect | −0.0041 | 0.0035 | 0.2479 | 0.0196 | 0.0038 | <0.0001 | - | - | ||
Indirect Effect | through C1 | −0.0032 | 0.0010 | 0.0014 |
Model: Cognitive decline = Demographic variables + Neuropathology + Postmortem R2 + Protein
Note: Cluster group 1 was mainly located in white matter while cluster group 2 was in grey matter.