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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neurobiol Aging. 2019 Jul 26;84:17–25. doi: 10.1016/j.neurobiolaging.2019.07.013

Table 2c.

Association of protein on cognitive decline after controlling demographic variables, neuropathology, and postmortem R2

Protein Cluster group1 Cluster group2

Beta se P Beta se P Beta se P
AK4 Direct effect −0.0094 0.0035 0.0074 0.0206 0.0037 <0.0001 −0.0112 0.0035 0.0014
Indirect Effect through C1 −0.0032 0.0011 0.0036
Indirect Effect through C2 −0.0019 0.0008 0.0175
ITPK1 Direct effect 0.0075 0.0036 0.0362 0.0147 0.0038 0.0001 - - -
Indirect Effect through C1 0.0025 0.0009 0.0077
IGFBP5 Direct effect −0.0142 0.0035 <0.0001 0.0185 0.0038 <0.0001 −0.0166 0.0036 <0.0001
Indirect Effect through C1 −0.0029 0.0010 0.0037
Indirect Effect through C2 −0.0031 0.0010 0.0019
HSPB2 Direct effect −0.0041 0.0035 0.2479 0.0196 0.0038 <0.0001 - -
Indirect Effect through C1 −0.0032 0.0010 0.0014

Model: Cognitive decline = Demographic variables + Neuropathology + Postmortem R2 + Protein

Note: Cluster group 1 was mainly located in white matter while cluster group 2 was in grey matter.