Table 3.
Age- and Sex-Specific Pediatric Reference Intervals for 13 Biochemical Markers Before and After Removing Subjects with Overweight/Obesity
| All Subjects | NW Subjects | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Analyte | Units | Age | Lower Limit | Upper Limit | n | Lower 90% Confidence Interval | Upper 90% Confidence Interval | Lower Limit | Upper Limit | n | Lower 90% Confidence Interval | Upper 90% Confidence Interval |
| ALT | U/L | 5-<13 y | 10 | 27 | 428 | (9 to 10) | (26 to 30) | 9 | 26 | 285 | (8 to 10) | (25 to 27) |
| 13-<19 y, F | 9 | 29 | 232 | (9 to 9) | (27 to 33) | 9 | 28 | 164 | (9 to 9) | (26 to 33) | ||
| 13-<19 y, M | 10 | 42 | 238 | (9 to 10) | (37 to 51) | 11 | 31 | 137 | (11 to 11) | (29 to 34) | ||
| ApoB | g/L | 5-<19 y | 0.31 | 0.86 | 834 | (0.29 to 0.32) | (0.84 to 0.92) | 0.28 | 0.83 | 567 | (0.27 to 0.31) | (0.79 to 0.86) |
| C3 | g/L | 5-<19 y | 0.87 | 1.63 | 765 | (0.85 to 0.88) | (1.57 to 1.69) | 0.79 | 1.47 | 536 | (0.78 to 0.82) | (1.44 to 1.51) |
| C4 | g/L | 5-<19 y | 0.13 | 0.4 | 818 | (0.12 to 0.13) | (0.38 to 0.41) | 0.12 | 0.38 | 557 | (0.12 to 0.13) | (0.36 to 0.39) |
| ChE | U/L | 5-<16 y | 8554 | 15712 | 536 | (8266 to 8745) | (15 219 to 16 069) | 8915 | 15667 | 339 | (8627 to 9086) | (14 996 to 16 021) |
| 16-<19 y, F | 7717 | 12387 | 86 | (7394 to 8034) | (1 1963 to 12 820) | 7068 | 12740 | 69 | (6499 to 7558) | (12 225 to 13 271) | ||
| 16-<19 y, M | 6763 | 14131 | 100 | (6159 to 7325) | (13 667 to 14 671) | 6891 | 13579 | 72 | (6185 to 7975) | (13 106 to 14 112) | ||
| hsCRP | mg/L | 5-<15 y | 0.1 | 9.6 | 596 | (0.1 to 0.1) | (7.6 to 11.3) | 0.1 | 7.6 | 404 | (0.1 to 0.1) | (5.8 to 10.4) |
| 15-<19 y | 0.1 | 14.0 | 299 | (0.1 to 0.1) | (10.1 to 20.6) | 0.1 | 12.0 | 210 | (0.1 to 0.1) | (7.7 to 17.5) | ||
| GGT | U/L | 5-<11 y | 8 | 17 | 261 | (7 to 9) | (16 to 19) | 9 | 17 | 171 | (9 to 9) | (16 to 21) |
| 11-<19 y | 8 | 175 | 594 | (7 to 9) | (147 to 197) | 8 | 49 | 361 | (8 to 9) | (38 to 54) | ||
| Haptoglobin | g/L | 5-<12 y | 0.07 | 1.53 | 319 | (0.07 to 0.07) | (1.40 to 1.67) | 0.07 | 1.38 | 221 | (0.07 to 0.07) | (1.25 to 1.63) |
| 12-<19 y | 0.07 | 1.71 | 473 | (0.07 to 0.07) | (1.61 to 1.77) | 0.07 | 1.72 | 328 | (0.07 to 0.07) | (1.61 to 1.79) | ||
| HDL-C | mmol/L | 5-<13 y | 0.59 | 1.91 | 397 | (0.52 to 0.71) | (1.87 to 1.99) | 0.52 | 1.93 | 271 | (0.46 to 0.59) | (1.88 to 2.05) |
| 13-<19 y, F | 0.56 | 1.79 | 238 | (0.49 to 0.66) | (1.71 to 1.85) | 0.88 | 1.91 | 159 | (0.85 to 0.94) | (1.85 to 1.99) | ||
| 13-<19 y, M | 0.58 | 1.75 | 235 | (0.51 to 0.66) | (1.63 to 1.84) | 0.64 | 1.76 | 151 | (0.53 to 0.78) | (1.63 to 1.84) | ||
| Iron | μmol/L | 5-<14 y | 5.0 | 25.9 | 382 | (4.2 to 5.5) | (24.0 to 27.3) | 5.5 | 25.9 | 252 | (4.8 to 6.8) | (24.0 to 27.2) |
| 14-<19 y | 5.2 | 32.9 | 297 | (3.8 to 6.0) | (28.8 to 33.5) | 5.2 | 31.0 | 208 | (3.8 to 6.2) | (27.5, 33.8) | ||
| Transferrin | g/L | 5-<19 y | 1.93 | 3.32 | 765 | (1.83 to 2.03) | (3.30 to 3.35) | 1.56 | 3.09 | 526 | (1.42 to 1.72) | (3.06 to 3.10) |
| Triglycerides | mmol/L | 5-<19 y | 0.52 | 3.00 | 873 | (0.49 to 0.55) | (2.84 to 3.35) | 0.50 | 2.81 | 604 | (0.47 to 0.54) | (2.51 to 3.03) |
| Uric acid | μmol/L | 5-<12 y | 125 | 418 | 343 | (119 to 132) | (373 to 473) | 114 | 374 | 236 | (101 to 123) | (333 to 428) |
| 12-<19 y, F | 158 | 511 | 272 | (150 to 162) | (463 to 533) | 144 | 451 | 192 | (121 to 157) | (385 to 488) | ||
| 12-<19 M | 204 | 571 | 267 | (174 to 210) | (524 to 615) | 190 | 536 | 176 | (156 to 210) | (521 to 580) | ||
Abbreviations: ALT, alanine aminotransferase; apoB, apolipoprotein B; C3, complement component 3; C4, complement component 4; ChE, cholinesterase; F, female-specific reference interval; GGT, gamma-glutamyl transferase; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; M, male-specific reference interval; NW, normal weight.