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. 2020 Mar 17;9:e54277. doi: 10.7554/eLife.54277

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© 2020, Hartwigsen et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 2. — (A) Lesion overlap for all patients. All patients had lesions in their left temporo-parietal cortex with the strongest overlap in the supramarginal gyrus. Note that the frontal cortex was intact in all patients. (B) Continuous theta burst stimulation (cTBS) sites over the left anterior and posterior inferior frontal gyrus (a/pIFG). Mean stimulation sites were taken from a previous study and transferred to the individual patient’s brain. (C) Effects of cTBS on task processing. Left panel: Relative to cTBS over aIFG or sham cTBS, cTBS of pIFG significantly delayed phonological response speed. The opposite pattern was found for semantic processing. Relative to cTBS over pIFG or sham cTBS, cTBS over aIFG significantly delayed semantic response speed. Right panel: Effects of cTBS on error rates were not significant. *p<0.05. (*) does not survive a Bonferroni-Holm correction for multiple comparisons. RTs = reaction times, SEM = standard error of the mean. Coordinates are given in MNI space.