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. 2020 Mar 17;9:e51928. doi: 10.7554/eLife.51928

Table 2. Precision measures, exact p-values, and replicate data relevant to Figure 2.

Figure Comparator 1 Comparator 2 Mean 1 Mean 2 SE of diff. N 1 N 2 Summary Adjusted
P Value
Figure 2h Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 77.63 Hz 49.18 Hz 7.497 18 14 ** 0.0020
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 77.63 Hz 55.97 Hz 7.355 18 15 * 0.0238
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 77.63 Hz 26.65 Hz 7.840 18 12 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 49.18 Hz 55.97 Hz 7.818 14 15 ns 0.8208
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 49.18 Hz 26.65 Hz 8.276 14 12 * 0.0419
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 55.97 Hz 26.65 Hz 8.148 15 12 ** 0.0037
Figure 2i Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 0.4902 1.372 0.2017 18 14 *** 0.0003
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 0.4902 1.152 0.1979 18 15 ** 0.0079
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.4902 1.953 0.2109 18 12 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 1.372 1.152 0.2103 14 15 ns 0.7229
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 1.372 1.953 0.2227 14 12 ns 0.0552
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 1.152 1.953 0.2192 15 12 ** 0.0032
Figure 2j Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 0.4443 0.6683 0.05314 18 14 *** 0.0005
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 0.4443 0.5355 0.05214 18 15 ns 0.3088
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.4443 0.8396 0.05558 18 12 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 0.6683 0.5355 0.05542 14 15 ns 0.0897
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.6683 0.8396 0.05867 14 12 * 0.0253
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.5355 0.8396 0.05776 15 12 **** <0.0001
Figure 2k Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 1.289 Hz 2.876 Hz 0.3641 18 14 *** 0.0003
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 1.289 Hz 1.458 Hz 0.3572 18 15 ns 0.9649
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 1.289 Hz 5.338 Hz 0.3807 18 12 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 2.876 Hz 1.458 Hz 0.3797 14 15 ** 0.0025
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 2.876 Hz 5.338 Hz 0.4019 14 12 **** <0.0001
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 1.458 Hz 5.338 Hz 0.3957 15 12 **** <0.0001
Figure 2l Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 0.7396 0.5753 0.07763 18 14 ns 0.1609
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 0.7396 0.8631 0.07617 18 15 ns 0.3751
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.7396 0.4335 0.08119 18 12 ** 0.0022
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 0.5753 0.8631 0.08096 14 15 ** 0.0043
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.5753 0.4335 0.08571 14 12 ns 0.3572
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.8631 0.4335 0.08438 15 12 **** <0.0001
Figure 2m Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 0.8876 0.5399 0.05937 18 14 **** <0.0001
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 0.8876 0.9082 0.05824 18 15 ns 0.9848
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.8876 0.3224 0.06209 18 12 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 0.5399 0.9082 0.06191 14 15 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.5399 0.3224 0.06554 14 12 ** 0.0085
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.9082 0.3224 0.06453 15 12 **** <0.0001
Figure 2n Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 0.008528 s 0.04651 s 0.009766 18 14 ** 0.0015
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 0.008528 s 0.02349 s 0.009581 18 15 ns 0.4089
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.008528 s 0.09622 s 0.01021 18 12 **** <0.0001
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 0.04651 s 0.02349 s 0.01018 14 15 ns 0.1202
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.04651 s 0.09622 s 0.01078 14 12 *** 0.0001
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.02349 s 0.09622 s 0.01061 15 12 **** <0.0001
Figure 2o Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 0.01806 s 0.01806 s 0.006551 18 14 ns >0.9999
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 0.01806 s 0.03709 s 0.006427 18 15 * 0.0228
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.01806 s 0.02643 s 0.006851 18 12 ns 0.6161
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 0.01806 s 0.03709 s 0.006831 14 15 * 0.0358
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.01806 s 0.02643 s 0.007232 14 12 ns 0.6560
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 0.03709 s 0.02643 s 0.007120 15 12 ns 0.4462
Figure 2p Slc32a1flox/flox baseline Slc32a1flox/flox
+ harmaline		 59.78 17.71 11.71 18 17 ** 0.0035
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox baseline 59.78 53.83 11.54 18 18 ns 0.9551
Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 59.78 8.421 12.10 18 15 *** 0.0004
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox baseline 17.71 53.83 11.71 17 18 * 0.0155
Slc32a1flox/flox
+ harmaline		 Pcp2Cre;Slc32a1flox/flox
+ harmaline		 17.71 8.421 12.26 17 15 ns 0.8730
Pcp2Cre;Slc32a1flox/flox baseline Pcp2Cre;Slc32a1flox/flox
+ harmaline		 53.83 8.421 12.10 18 15 ** 0.0021