ChiCTR‐INR‐16009781.

Trial name or title	The clinical application and significance of ocular surface function and tear lipid layer examination
Methods	Study design: randomised controlled trial Study grouping: parallel group Exclusions after randomisation? Not reported Percentage of participant follow‐up: not applicable Study duration (of intervention): not reported Was a sample size calculation reported: not reported
Participants	Baseline characteristics Standard therapy group Number of participants (number of eyes): 25 (not reported) Sex: not reported Age: not reported IPL group Number of participants (number of eyes): 25 (not reported) Sex: not reported Age: not reported LipiFlow Number of participants (number of eyes): 25 (not reported) Sex: not reported Age: not reported Overall Number of participants (number of eyes): 75 (not reported) Sex: not reported Age: not reported Inclusion criteria: aged 18–80 years; willing to follow study protocol; diagnosed with MGD; SPEED score ≥ 6; meibomian gland secretion score ≤ 12 for 15 glands of the lower lid; complete informed consent. Exclusion criteria: pregnant or breastfeeding woman; SPEED score ≥ 15; meibomian gland dropout area of any lower lid ≥ 50%; any co‐existing ocular conditions that could interfere with dry eye (e.g. use of systemic antihistamines, anti‐inflammatory drugs or corticosteroids); any co‐existing ocular conditions that could interfere with treatment (e.g. Fitzpatrick skin type VI). Significant pretreatment baseline differences? Not reported Severity of dry eye: not reported
Interventions	Standard therapy Description: warming eye mask Duration: not reported Co‐interventions: not reported IPL Description: IPL Duration: not reported Co‐interventions: not reported LipiFlow Description: LipiFlow Duration: not reported Co‐interventions: not reported
Outcomes	Primary outcomes: OSDI SPEED BUT LLT Secondary outcome: TMH (Time points not reported in clinical trial registry)
Starting date	Not yet recruiting (as of 18 September 2019)
Contact information	Study leader: Billian Ke 100 Haining Road, Hongkou District, Shanghai, China Email: kebilian@126.com Telephone: +86 13386259873
Notes	None